Alternative Therapy and Treatment of Type 2 Diabetes

The rise in prevalence and incidence of type 2 diabetes mellitus (T2D) in the developing world continues unabated. Current treatment strategies, however, fall short of achieving optimal glycemic control. The aim of project I was to investigate the effect of an acute bout of a yogic breathing exercise on heart rate variability (HRV) in individuals with T2D. Project II was designed to assess the effectiveness of the neurohormone melatonin in lowering short- and long-term glucose levels, lipids and oxidative stress in T2D. Project III investigated the differential effects of two different styles of aerobic exercise on postprandial glycemia, mood and HRV in T2D. Project I investigated the effect of short-term breathing exercises and demonstrated significant differences between the T2D group and an age-matched normoglycemic group (CON) in resting measures of HRV. Standard deviation of consecutive heart beats (SDNN), the square root of the mean squared differences (RMSSD) and total spectral power (TP) were almost uniformly lower in the T2D group than the CON group. A within-group analysis revealed no significant effect of breathing exercise upon HRV in the CON group. However, a 10-minute breathing protocol involving selective breathing through only the left nostril demonstrated a significant reduction in resting heart rate in the T2D group (-1.2 beats per minute, or bpm) compared to the heart rate average during the entire breathing protocol, indicating a possible acute improvement in vagal tone. Project II, which investigated the effect of six weeks of melatonin supplementation on short-and long-term glycemic control, lipids, and oxidative stress in T2D, yielded impressive results. There was a significant reduction in malondialdehyde, a marker of oxidative stress (-6.3 vs. 0.7nmol/ml), as well as a significant drop in glycated hemoglobin (-0.24%±0.23) in the melatonin group vs. the placebo group. Project III examined the impact of a more recreational style of exercise (table tennis) following a dinner meal vs. a more traditional exercise (walking). Our results indicated that self-paced walking generated a significantly higher heart rate than table tennis, which translated into a significant drop in blood glucose levels following a 30-minute bout of exercise. We did not, however, note any difference in mood between the two groups

Exercise in the Treatment and Prevention of Diabetes

The inclusion of regular physical activity is critical for optimal insulin action and glycemic control in individuals with diabetes. Current research suggests that Type II diabetes mellitus can be prevented and that all types of diabetes can be controlled with physical activity, largely through improvements in muscular sensitivity to insulin. This article discusses diabetes prevention and the acute and chronic benefits of exercise for individuals with diabetes, along with the importance and impact of aerobic, resistance, or combined training upon glycemic control. To undertake physical activity safely, individuals also must learn optimal management of glycemia

Metronomic Chemotherapy with Vinorelbine Produces Clinical Benefit and Low Toxicity in Frail Elderly Patients Affected by Advanced Non-Small Cell Lung Cancer

Lung cancer is the leading cause of death worldwide. The treatment choice for advanced stage of lung cancer may depend on histotype, performance status (PS), age, and comorbidities. In the present study, we focused on the effect of metronomic vinorelbine treatment in elderly patients with advanced unresectable non-small cell lung cancer (NSCLC). Methods. From January 2016 to December 2016, 44 patients affected by non-small cell lung cancer referred to our oncology day hospital were progressively analyzed. The patients were treated with oral vinorelbine 30 mg x 3/wk or 40 mg x 3/wk meaning one day on and one day off. The patients were older than 60, stage IIIB or IV, ECOG PS ≥ 1, and have at least one important comorbidity (renal, hepatic, or cardiovascular disease). The schedule was based on ECOG-PS and comorbidities. The primary endpoint was progression-free survival (PFS). PFS was used to compare patients based on different scheduled dosage (30 or 40 mg x3/weekly) and age (more or less than 75 years old) as exploratory analysis. We also evaluated as secondary endpoint toxicity according to Common Toxicity Criteria Version 2.0. Results. Vinorelbine showed a good safety profile at different doses taken orally and was effective in controlling cancer progression. The median overall survival (OS) was 12 months. The disease control rate (DCR) achieved 63%. The median PFS was 9 months. A significant difference in PFS was detected comparing patients aged below with those over 75, and the HR value was 0.72 (p<0.05). Not significant was the difference between groups with different schedules. Conclusions. This study confirmed the safety profile of metronomic vinorelbine and its applicability for patients unfit for standard chemotherapies and adds the possibility of considering this type of schedule not only for very elderly patients

A Scalable Cluster-based Infrastructure for Edge-computing Services

In this paper we present a scalable and dynamic intermediary infrastruc- ture, SEcS (acronym of BScalable Edge computing Services’’), for developing and deploying advanced Edge computing services, by using a cluster of heterogeneous machines. Our goal is to address the challenges of the next-generation Internet services: scalability, high availability, fault-tolerance and robustness, as well as programmability and quick prototyping. The system is written in Java and is based on IBM’s Web Based Intermediaries (WBI) [71] developed at IBM Almaden Research Center

Sustaining the Spindle Assembly Checkpoint to improve cancer therapy

To prevent chromosome segregation errors, the spindle assembly checkpoint (SAC) delays mitosis exit until proper spindle assembly. We found that the FCP1 phosphatase and its downstream target WEE1 kinase oppose the SAC, promoting mitosis exit despite malformed spindles. We further showed that targeting this pathway might be useful for cancer therapy

Does degradation from selective logging and illegal activities differently impact forest resources? A case study in Ghana

Degradation, a reduction of the ecosystem’s capacity to supply goods and services, is widespread in tropical forests and mainly caused by human disturbance. To maintain the full range of forest ecosystem services and support the development of effective conservation policies, we must understand the overall impact of degradation on different forest resources. This research investigates the response to disturbance of forest structure using several indicators: soil carbon content, arboreal richness and biodiversity, functional composition (guild and wood density), and productivity. We drew upon large field and remote sensing datasets from different forest types in Ghana, characterized by varied protection status, to investigate impacts of selective logging, and of illegal land use and resources extraction, which are the main disturbance causes in West Africa. Results indicate that functional composition and the overall number of species are less affected by degradation, while forest structure, soil carbon content and species abundance are seriously impacted, with resources distribution reflecting the protection level of the areas. Remote sensing analysis showed an increase in productivity in the last three decades, with higher resiliency to change in drier forest types, and stronger productivity correlation with solar radiation in the short dry season. The study region is affected by growing anthropogenic pressure on natural resources and by an increased climate variability: possible interactions of disturbance with climate are also discussed, together with the urgency to reduce degradation in order to preserve the full range of ecosystem functions